个人简介

李启明，微生物学博士，硕士生导师，主要研究病原微生物与宿主互作及新型抗感染药物研发，邮箱liqiming82@126.com

主持或参加的科研课题

河南省高等学校重点科研项目 2020.01-2021.12  主持  已结项

河南省自然科学基金青年基金2020.01-2022.12   主持  已结项

中国博士后科学基金第68批面上项目2020.01-2021.12  主持  已结项

开封市科技发展计划项目（科技攻关）2024.01-2025.12 主持  已结项

河南省科技攻关项目 2024.01-2025.12 主持  已结项

河南省医学科技攻关计划项目 2025.01-2027.12 主持  在研

代表性期刊论文

1. Li Qiming, Li Jiaqi, Zhao Yanyang, Guo Shuai, Liu Mengzhe, Shi Xiaoyu, Wang Li, Liu Zhigang*, Teng Tieshan*. Characterization and genomics of phage Henu2_3 against K1 Klebsiella pneumoniae and its efficacy in animal models. AMB Express. 2025 Jul 30;15(1):112. （第一作者, 中科院二区，IF=3.7）

2. Fang Zhou†, Kexiao Wang†, Shuai Ji, Xiaochen Liao, Wenwen Zhang, Tieshan Teng, Li Wang*, Qiming Li*.The virulent bacteriophage Henu8 as an antimicrobial synergist against Escherichia coli. Microbiology Spectrum. 2025 Jul;13(7):e0163324. （通讯作者, 中科院二区, IF=3.8）

3. Guo Weikai*, Yang Zhengfan, Wang Kexiao, Li Wenyu, Zhao Yanyang, Yang Yuqing, Chang Wenjing, Gong Zhen, Liu Zhou, Chen Yihua*, Li Qiming*. Discovery of Unique Bis-Substituted Aromatic Amide Derivatives as Novel Highly Potent Antibiotics for Combating Methicillin-Resistant Staphylococcus aureus (MRSA). J Med Chem. 2024 Feb 8;67(3):2129-2151. （通讯作者, 中科院一区Top，IF = 7.3）

4. Guo Xiaoge, Zhang Jing, Wang Yuhan, Zhou Fang, Li Qiming*, Teng Tieshan*. Phenotypic Characterization and Comparative Genomic Analyses of Mycobacteriophage WIVsmall as A New Member Assigned to F1 Subcluster. Curr Issues Mol Biol. 2023 Aug 3;45(8):6432-6448. （通讯作者, 中科院四区，IF=3.1）

5. Wang Guoying, Cai Linghao, Chen Dandan, Teng Tieshan*, Li Qiming*, Xie Longxiang*. Influence of COVID-19 in patients with concurrent tuberculosis coinfections. J Med Virol. 2021 Apr;93(4):1937-1939. （通讯作者，中科院三区，IF=12.7）

6. Wang Zekun, Ren Songyang, Li Qiming, Royster Austin D, Lin Lei, Liu Sichen, Ganaie Safder S, Qiu Jianming, Mir Sheema, Mir Mohammad A. Hantaviruses use the endogenous host factor P58IPK to combat the PKR antiviral response. PLoS Pathog. 2021 Oct 15;17(10):e1010007. (中科院一区Top，IF=6.7)

7. Hong Yuzhi#, Li Qiming#, Gao Qiong, Xie Jianping, Huang Haihui, Drlica Karl, Zhao Xilin. Reactive oxygen species play a dominant role in all pathways of rapid quinolone-mediated killing. J Antimicrob Chemother. 2020 Mar 1;75(3):576-585. （共同第一作者，中科院一区Top，IF=5.2）

8. Li Qiming, Longxiang Xie, Quanxin Long, Jinxiao Mao, Hui Li, Mingliang Zhou, and Jianping Xie. "Proteasome Accessory Factor C (pafC) Is a novel gene Involved in Mycobacterium Intrinsic Resistance to broad-spectrum antibiotics-Fluoroquinolones." Scientific reports 5 (2015): 11910.

9. Li Qiming, Mingliang Zhou#, Xiangyu Fan, Jianlong Yan, Weimin Li, and Jianping Xie. "Mycobacteriophage SWU1 gp39 can potentiate multiple antibiotics against Mycobacterium via altering the cell wall permeability." Scientific reports 6 (2016).

10. Li Qiming#, Tiwei Fu#, Chunyan Li, Xiangyu Fan, and Jianping Xie. "Mycobacterial IclR family transcriptional factor Rv2989 is specifically involved in isoniazid tolerance by regulating the expression of catalase encoding gene katG." RSC Advances 6, no. 60 (2016): 54661-54667.

11. Li Qiming, Chunyan Li, Longxiang Xie, Chenhui Zhang, Yonghong Feng, and Jianping Xie. "Characterization of a putative ArsR transcriptional regulator encoded by Rv2642 from Mycobacterium tuberculosis." Journal of Biomolecular Structure and Dynamics 35, no. 9 (2017): 2031-2039.

12. Li Hui#, Qiming Li#, Zhaoxiao Yu, Mingliang Zhou, and Jianping Xie. "Mycobacterium tuberculosis PE13 (Rv1195) manipulates the host cell fate via p38-ERK-NF-κB axis and apoptosis." Apoptosis 21, no. 7 (2016): 795-808. （共同第一作者）

13. LinYanping#, Qiming Li#, Longxiang Xie, and Jianping Xie. "Mycobacterium tuberculosis Rv1400c encodes functional lipase/esterase." Protein expression and purification 129 (2017): 143-149. （共同第一作者）

14. Teng Tieshan#, Li Qiming#, Liu Zhengguo, Li Xianghui, et al: Characterization and genome analysis of novel Klebsiella phage Henu1 with lytic activity against clinical strains of Klebsiella pneumoniae. Archives of Virology 2019. （共同第一作者）

授权发明专利：

一类氮原子双取代芳香环类小分子有机化合物及其衍生物及其在制备抗菌药物中的应用 发明专利 2025年07月08日 郭伟凯;李启明;李文雨;杨雨青;王柯晓;赵艳阳 ZL 2023 1 0919809.3