个人简介                             

赵世振，博士，副教授，硕士生导师，开封市科技创新人才，河南省微生物学会理事。主持国家自然科学基金青年项目1项、中国博士后面上项目一等资助1项、河南省自然科学基金面上项目1项、河南省重点研发与推广专项3项、河南省博士后科学项目1项、河南省高等学校重点科研项目1项、河南省医学科技攻关1项、河南大学青年交叉基金项目1项，指导6项大学生创新创业训练计划项目，并参与多项国家和省部级项目的研究工作。近年来以第一作者或通讯作者在Journal of Medicinal Chemistry，Analytical Chemistry，European Journal of Medicinal Chemistry，Bioorganic & Medicinal Chemistry等SCI期刊上发表SCI论文13篇，其中SCI一区以上论文3篇，二区论文4篇，授权国家发明专利5项。本人邮箱：zhaoshizhen1987@163.com。

研究方向

基于靶点的药物设计与药效评价

主持的科研课题

1. 国家自然科学基金委员会，青年项目，81903444，FXR/TGR5双靶点激动剂的设计、优化及生物活性评价，2020-01至2022-12，21万元，结题，主持
2. 河南省重点研发与推广专项，192102310145，非甾体类FXR/TGR5双靶点激动剂的设计及生物活性研究. 2019/01-2020/12，10万元，结题，主持
3. 中国博士后科学基金会，面上资助（一等），2018M640674，非甾体类FXR激动剂的设计及机制研究，2018-09至2020-08，8万元，结题，主持
4. 河南省重点研发与推广专项，232102310398，肠道靶向非系统性TGR5/ GPR119 双靶点激动剂的设计及降糖活性研究，2023/01-2024/12，在研，主持
5. 河南省自然科学基金，面上项目，242300420100，基于肠黏附性非体循环策略的 TGR5 激动剂的设计、合成及活性研究. 2024/01-2025/12, 在研，主持
6. 河南省重点研发与推广专项，252102311215，结肠靶向TGR5激动剂与5-氨基水杨酸偶氮前药的设计、合成及在炎症性肠病中的作用，2025/01-2026/12，10万元，在研，主持

获奖情况

2021年     河南省教育厅科技成果奖   一等奖   第四

2025年     开封市自然科学优秀论文奖  三等奖   第一

2024年     开封市科技创新人才

发表的期刊论文

1. Juan Cen; Ping Lu; Chenwei Wang; Jing Wu; Xiaojiao Hu; Han Zhao; Mengyu Li; Mingkai Luo; Shizhen Zhao*; Xiaohui Li*; Shaofeng Duan*.Double Swords in One: Novel Selective PI3K/110β PROTAC Degraders for the Treatment of Multidrug-Resistant Cancer by Activating ERS and Inhibiting P-gp. Journal of Medicinal Chemistry, 2025;68(9):9446-9464. (SCI一区，TOP)
2. Shizhen Zhao; Le Wanb; Xiaotong Huang; Yali Xiao; Mengqi Li; Xueyuan Huang; Xueyu Chen; Shengjie Li; Jing Xie; Peng Liu; Yan-Dong Wang; Wei-Dong Chen. Design, Synthesis, and Biological Evaluation of Covalently Mucoadhesive Derivatives as Nonsystemic Intestine-Targeted TGR5 Agonists. Journal of Medicinal Chemistry, 2024, 67(19):17701-17712. (SCI一区，TOP)
3. Yingli Ye; Xueyu Chen; Yanbing Lv*; Tianxin Li; Yuning Zhang; Nan Jiang ; Shizhen Zhao*; Ruili Wu; Huaibin Shen; Linsong Li*. Tailored Quantum Dots@Metal-Organic Frameworks for Enhanced Hypochlorite Detection in Live Cells and Ulcerative Colitis Diagnosis. Analytical chemistry, 2025, 97(31):16916-16924. (SCI一区，TOP)
4. Shizhen Zhao; Xiangqian Zhang; Peng Wei; Xin Su; Liyu Zhao; Mengya Wu; Chenzhou Hao; Chunchi Liu; Dongmei Zhao*; Maosheng Cheng; Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents, European Journal of Medicinal Chemistry, 2017, 137:96-107. 
5. Shizhen Zhao; Liyu Zhao; Xiangqian Zhang; Chunchi Liu; Chenzhou Hao; Honglei Xie; Bin Sun; Dongmei Zhao*; Maosheng Cheng; Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents, European Journal of Medicinal Chemistry, 2016, 123:514-522.
6. Shizhen Zhao, Honggang Wang*.EVA1A plays an important role by regulating autophagy in physiological and pathological processes. International journal of molecular sciences, 2021, 22(12):6181. 
7. Zhao Shizhen; Wang Le; Wang Jie; Wang Chenwei; Zheng Shaowei; Fu Yajie; Li Yunfu; Chen Wei-Dong; Hou Ruifang; Yang Dongbin; Wang Yan-Dong. Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists. RSC Advances, 2022, 6: 3618-3629.
8. Yajie Fu; Yanzhi Zhou; Linhu Shen; Xuewen Li; Haorui Zhang; Yeqi Cui; Ke Zhang; Weiguo Li; Wei-dong Chen; Shizhen Zhao*; Yunfu Li*; Wenling Ye*. Diagnostic and therapeutic strategies for non-alcoholic fatty liver disease. Frontiers in Pharmacology, 2022, 13: 973366.
9. Shizhen Zhao; Xinping Li; Le Wang; Wenjing Peng; Wenling Ye; Weiguo Li; Yan-Dong Wang; Wei-Dong Chen*. Design, synthesis and evaluation of 1-benzyl-1H-imidazole-5-carboxamide derivatives as potent TGR5 agonists. Bioorganic & medicinal chemistry, 2021, 32: 115972.
10. Shizhen Zhao; Wenjing Peng; Xinping Li; Le Wang; Wenbo Yin; Yan- Dong Wang; Ruifang Hou*; Wei-Dong Chen*. Pharmacophore modeling and virtual screening studies for discovery of novel farnesoid X receptor (FXR) agonists. RSC Advances, 2021, 11: 2158-2166.
11. Shizhen Zhao, Xinping Li, Wenjing Peng, Le Wang, Wenling Ye, Yang Zhao, Wenbo Yin, Wei-Dong Chen, Weiguo Li*, Yan-Dong Wang*. Ligand-Based pharmacophore modeling, Virtual screening and Biological Evaluation to identify novel TGR5 agonists. RSC Advances, 2021, 11: 9403-9409.
12. Shizhen Zhao, Liyu Zhao, Xiangqian Zhang, Peng Wei, Mengya Wu, Xin Su, Bin Sun, Dongmei Zhao*, Maosheng Cheng. Design, synthesis and evaluation of biphenyl imidazole analogues as potent antifungal agents. Bioorganic & Medicinal Chemistry Letters, 2019, 29: 2448-2451.
13. Shizhen Zhao; Peng Wei; Mengya Wu; Xiangqian Zhang; Liyu Zhao; Xiaolin Jiang; Chenzhou Hao; Xin Su; Dongmei Zhao*; Maosheng Cheng; Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51, Bioorganic & Medicinal Chemistry, 2018, 26:3242-3253.
14. Yanan Dong , Peiju Yang , Shizhen Zhao , Yuehui Li*. Reductive cyanation of organic chlorides using CO2 and NH3 via Triphos-Ni(I) species. Nature Communication. 2020;11(1):4096. 
15.  

授权发明专利

1.赵冬梅, 赵世振, 程卯生, 赵立雨, 张向前, 魏鹏, 吴梦雅, 王德鑫. 三环异恶唑类衍生物及其制备方法和应用，2019-05-17，中国，ZL 201710422321.4.

2.赵冬梅, 赵世振, 孙彬, 程卯生, 李凤荣, 赵立雨, 郝晨洲, 刘春池, 任金红. 酰胺咪唑类衍生物及其用途，2019-02-25，中国，ZL 201510895760.8.

3.赵冬梅, 赵世振, 孙彬, 程卯生, 李凤荣, 赵立雨, 郝晨洲, 刘春池, 任金红. 苯并噻唑类衍生物及其用途，2020-08-04，ZL 201811434187.0. 

4.陈卫东, 赵世振, 王艳东, 叶文凌, 聂小博, 彭雯婧, 李新萍. 咪康唑及其衍生物作为TGR5激动剂的应用, 2022-06-21，ZL 201911257035.2.

5.陈卫东; 赵世振; 王艳东; 叶文凌; 聂小博; 周云; 李新萍. 苯乙基咪唑类衍生物及其用途, 2022-11-01, ZL 202010671930.5.