王森震
个人简介
王森震,33岁,2016年毕业于山东第二医科大学药学专业,获理学学士学位;2019年毕业于河南大学药物化学专业,获硕士学位,2024年毕业于河南大学生物学专业,获博士学位。参与发表SCI论文12篇,参与发明专利2项,参与国自然项目3项。自毕业以来,入职河南大学第一附属医院从事博士后工作,研究领域主要为抗肿瘤药物研发和自身免疫性疾病药效学研究。本人邮箱wangsz8836@vip.henu.edu.cn
获奖情况
鲁蒙蒙,郭政伟,王森震(排名3/获奖人数5),刘慧阳,刘征,靶向肿瘤特异性和组织/器官特异性的递送系统技术的开发项目,国家人力资源和社会保障部,第一届全国博士后创新创业大赛,入围总决赛奖励证书,2021年
主持或参加科研项目情况
1. 国家自然科学基金联合基金项目,U1904151,基于转录组学研究内质网应激下ATF4介导的 SESN2调控在逆转肿瘤阿霉素耐药中的作用及机制,2020-01-01至2022-12-31,49万元,在研,参与
代表性研究成果
1. Senzhen Wang, Xiaojuan Xu, Delu Che, Ronghui Fan, Mengke Gao, Yue Cao, Chaochao Ge, Yongli Feng, Jinghua Li, Songqiang Xie, Chaojie Wang, Fujun Dai*, Lei Gao, Yuxia Wang*. Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma. International Journal of Molecular Sciences, 2021, 22(20): 10987.
2. Ronghui Fan#, Senzhen Wang#, Yalan Wu, Yongli Feng, Mengke Gao, Yue Cao, Xiaoxuan Ma, Songqiang Xie, Chaojie Wang, Lei Gao*, Yanming Wang*, Fujun Dai*. Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma. Phytotherapy Research, 2023, 37(10): 4655-4673 (共同第一作者)
3. Xiaojuan Xu#, Senzhen Wang#, Yuan Chang, et al. Synthesis and biological evaluation of novel asymmetric naphthalene diimide derivatives as anticancer agents depending on ROS generation. Medchemcomm , 2018 Aug 1;9(8):1377-1385 (共同第一作者)
4. Chaochao Ge, Yuxia Wang, Yongli Feng, Senzhen Wang, Kemeng Zhang, Xiaojuan Xu, ZhiyangZhang, Yuan Zhao, Yanming Wang, Lei Gao, Fujun Dai*, Songqiang Xie*, Chaojie Wang*. Suppression of oxidative phosphorylation and IDH2 sensitizes colorectal cancer to a naphthalimide derivative and mitoxantrone. Cancer Letters, 2021, 519: 30-45.
5. Lei Gao, Chaochao Ge, Senzhen Wang, Xiaojuan Xu, Yongli Feng, Xinna Li, Chaojie Wang, Yuxia Wang, Fujun Dai*, Songqiang Xie*. The Role of p53-Mediated Signaling in the Therapeutic Response of Colorectal Cancer to 9F, a Spermine-Modified Naphthalene Diimide Derivative. Cancers, 2020, 12(3): 528.
6. Lei Gao, Yongli Feng, Chaochao Ge, Xiaojuan Xu, Senzhen Wang, et al. Identification of molecular anti-metastasis mechanisms of lycorine in colorectal cancer by RNA-seq analysis. Phytomedicine,(Q1, 中科院二区), 2021, 85(0):153530
授权发明专利
1. 代付军,高蕾,徐小娟,王森震,王玉霞,谢松强,王超杰, 萘酰亚胺-多胺衍生物联合环孢素A在制备抑制血管新生药物中的应用, 2022-03-15, 中国, CN202110600529.7
2. 代付军,王超杰,谢松强,徐小娟,王玉霞,王森震,戈超超,冯永丽,车得路,范荣辉,曹越,高梦柯,萘酰亚胺-多胺衍生物联合环孢素A在制备抗肿瘤药物中的应用, 2022-01-25, 中国, CN202110346481.1