个人简介

张媛，女，助理教授。2015年6月毕业于武汉大学微生物学专业，获理学博士学位。次年8月赴美国克利夫兰临床医学中心从事博士后研究，于2024年9月回国并加入河南大学第一附属医院科研部。入选河南省“中原英才计划”青年组。联系方式：yuanzhang@henu.edu.cn。

研究方向

主要研究分泌蛋白在细胞内的转运过程和途径，特别是由货物受体介导的货物蛋白（如凝血因子VIII，凝血因子V ，α1-抗胰蛋白酶等）从内质网到高尔基体的转运机制和分泌调控。

奖励荣誉

2019年，西班牙基立福（Grifols）公司，α1-抗胰蛋白酶劳雷尔科研训练奖（ALTA）

2021年，美国国立出血性疾病基金会，朱迪丝•格雷汉姆•玻尔博士后研究奖学金

发表论文

1.  Srivastava V, Liu Z, Wei W, Zhang Y, Paton JC, Paton AW, Mu T, Zhang B. Cell-Based Small-Molecule Screening Identifying Proteostasis Regulators Enhancing Factor VIII Missense Mutant Secretion. Biomolecules. 15, 458. 2025

2.  Zhang Y, Liu Z, Zhang B. Separate roles of LMAN1 and MCFD2 in ER-to-Golgi trafficking of FV and FVIII. Blood Advances. 7(7): 1286-1296. 2023. (IF: 7.6，中科院一区)

3. Zhang Y, Srivastava V, Zhang B. Mammalian cargo receptors for endoplasmic reticulum to Golgi transport: mechanisms and interactions. Biochemical Society Transactions. 51(3): 971-981. 2023 (IF: 3.9，中科院三区)

4. Miller MH, Swaby LG, Vailoces VS, LaFratta M, Zhang Y, Zhu X, Hitchcock DJ, Jewett TJ, Zhang B, Tigno-Aranjuez JT. LMAN1 is a receptor for house dust mite allergens. Cell Reports. 42(3):112208. 2023.

5. Zhang Y, Zhu M, Zheng C, Wei W, Emmer B, Zhang B. LMAN1-MCFD2 complex is a cargo receptor for the ER-Golgi transport of α1-antitrypsin. Biochemical Journal. 479(7): 839-855. 2022. (IF: 4.1，中科院三区)

6. Liu Z, Zhang Y, Zhu M, Zhang B. Identification of candidate nonsense mutations of FVIII for ribosomal readthrough therapy. Haematologica. 104(12): e573-e576. 2019.

7. Chang IJ, Byers HM, Ng BG, Merritt JL, Gilmore R, Shrimal S, Wei W, Zhang Y, Blair AB, Freeze HH, Zhang B, Lam C. Factor VIII and vWF deficiency in STT3A-CDG. Journal of Inherited Metabolic Disease. 42(2):325-332. 2019.

8. Zhang Y, Qiao L, Hu X, Zhao K, Zhang Y, Chai F, Pan Z. Baculovirus vectors expressing F proteins in combination with virus-induced signaling adaptor (VISA) molecules confer protection against respiratory syncytial virus infection. Vaccine. 34(2):252-260. 2016. (IF: 3.2，中科院二区)

9. Qiao L, Zhang Y, Chai F, Tan Y, Huo C, Pan Z. Chimeric virus-like particles containing a conserved region of the G protein in combination with a single peptide of the M2 protein confer protection against respiratory syncytial virus infection. Antiviral Research. 131:131-140. 2016.

10. Luo M, Qu X, Pan R, Zhu D, Zhang Y, Wu J, Pan Z. The virus-induced signaling adaptor molecule enhances DNA-raised immune protection against H5N1 influenza virus infection in mice. Vaccine. 29(14):2561-2567. 2011.